[Linkage studies of a familial spastic paraplegia pedigree from Tibet]

H Li; S Huang; Y Zhu; B La; Z Bai; Y Mu; C Fischer; F Vogel; W H Lo

[Linkage studies of a familial spastic paraplegia pedigree from Tibet]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1999 Feb 10;16(1):5-8.

[Article in Chinese]

Authors

H Li¹, S Huang, Y Zhu, B La, Z Bai, Y Mu, C Fischer, F Vogel, W H Lo

Affiliation

¹ Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005 P. R. China.

PMID: 9949231

Abstract

Objective: To study the location of disease-related gene in a hereditary spastic paraplegia family with autosomal dominant inheritance in Tibet.

Methods: The AD-HSP family in Tibet was analyzed by linkage studies using 9 highly polymorphic microsatellite DNA markers at three chromosomal regions.

Results: The maxium Lod- Score of D14S264 was 0.5163(theta=0.05); of D14S75, 2. 1072 (theta=0);+D14S69, 0.2840 (theta=0.10); of D14S266, 0.9311 (theta=0);of D14S66, 0.7991(theta=0);OF GABRB3, 0(theta =0.40);of D15S128, 0(theta=0.40); of D2S2255, 0 (theta=0.40);and of D2S2347,0(theta=0.40).

Conclusion: In this Tibetian family, the disease-related gene is linked to D14S75 locus of SPG3 region.

Publication types

English Abstract

MeSH terms

Female
Genetic Linkage*
Humans
Male
Pedigree
Polymerase Chain Reaction
Spastic Paraplegia, Hereditary / genetics*
Tandem Repeat Sequences
Tibet