Synthesis and phototoxic property of tetra- and octa-glycoconjugated tetraphenylchlorins

Y Mikata; Y Onchi; M Shibata; T Kakuchi; H Ono; S Ogura; I Okura; S Yano

doi:10.1016/s0960-894x(98)00645-3

Synthesis and phototoxic property of tetra- and octa-glycoconjugated tetraphenylchlorins

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3543-8. doi: 10.1016/s0960-894x(98)00645-3.

Authors

Y Mikata¹, Y Onchi, M Shibata, T Kakuchi, H Ono, S Ogura, I Okura, S Yano

Affiliation

¹ Department of Chemistry, Faculty of Science, Nara Women's University, Japan.

PMID: 9934468
DOI: 10.1016/s0960-894x(98)00645-3

Abstract

New tetraphenylchlorin derivatives having four or eight glucose molecules were synthesized. Phototoxicity against the HeLa cell, singlet oxygen producing ability, and cell permeability were examined to evaluate the activity on photodynamic therapy of the compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glycoconjugates / chemistry*
HeLa Cells
Humans
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology*
Porphyrins / chemical synthesis*
Porphyrins / chemistry
Porphyrins / pharmacology*
Spectrum Analysis

Substances

Glycoconjugates
Photosensitizing Agents
Porphyrins
chlorin