Adding water to liquid scintillation cocktail for laboratory wipe tests

Health Phys. 1999 Feb;76(2 Suppl):S32-6. doi: 10.1097/00004032-199902001-00009.

Abstract

As part of an ongoing laboratory survey process improvement program, we evaluated the addition of water to liquid scintillation cocktail to improve wipe test counting efficiency. Both polar and non-polar 3H and 14C-labeled compounds were used as model contaminants. Our results support the recommendations in the literature regarding the addition of water to scintillation cocktail We found an increase in the counting efficiency of the water-soluble material as a function of water content of the cocktail, but also observed a decrease in the efficiency of detection of the non-polar compound. The offsetting effects are believed to be the result of increased solubility of the polar compounds in water and increased quench of the already solubilized non-polar compound. The finding that adding water to the cocktail brought counting efficiencies of both polar and non-polar molecules to roughly the same value is novel and allows the use of a single quench curve for each radionuclide, regardless of chemical form.

MeSH terms

  • Carbon Radioisotopes / analysis
  • Humans
  • Laboratories
  • Radiation Monitoring / methods*
  • Reproducibility of Results
  • Scintillation Counting / methods*
  • Sensitivity and Specificity
  • Solubility
  • Thymidine / analysis
  • Total Quality Management
  • Tritium / analysis
  • Water*

Substances

  • Carbon Radioisotopes
  • Water
  • Tritium
  • Thymidine