Abstract
Twelve SHV-type extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli lac mutant isolates were recovered in October 1997 from 11 patients of the neonatal ward in a Warsaw hospital. The outbreak was clonal; however, some of the isolates expressed a much higher level of resistance to several beta-lactam antibiotics, including expanded-spectrum cephalosporins. This phenotype has been attributed to beta-lactamase hyperproduction correlating with the multiplication of ESBL gene copies, as was demonstrated for representative isolates.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cephalosporin Resistance / genetics*
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Cephalosporins / pharmacology*
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Cross Infection / epidemiology
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Cross Infection / microbiology*
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Disease Outbreaks*
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Escherichia coli / drug effects*
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Escherichia coli / enzymology
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Escherichia coli / genetics
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Escherichia coli Infections / epidemiology*
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Escherichia coli Infections / microbiology
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Gene Dosage
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Humans
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Microbial Sensitivity Tests
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Phenotype
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Poland / epidemiology
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beta-Lactamases / biosynthesis*
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beta-Lactamases / genetics
Substances
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Cephalosporins
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beta-lactamase SHV-5
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beta-Lactamases