Vinorelbine-related acute cardiopulmonary toxicity

Cancer Chemother Pharmacol. 1999;43(2):180-2. doi: 10.1007/s002800050882.

Abstract

Three cases of possible acute cardiopulmonary toxicity following the administration of vinorelbine are reported. The symptoms mimicked acute cardiac ischemia. However, neither ECG changes nor elevations of serum enzymes were observed. The outcome is favorable in 90% of patients developing this adverse event. The putative mechanism remains to be elucidated.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Chest Pain / chemically induced
  • Dyspnea / chemically induced
  • Female
  • Humans
  • Middle Aged
  • Myocardial Ischemia / chemically induced*
  • Pulmonary Edema / chemically induced*
  • Vinblastine / adverse effects
  • Vinblastine / analogs & derivatives*
  • Vinorelbine

Substances

  • Antineoplastic Agents, Phytogenic
  • Vinblastine
  • Vinorelbine