Abstract
A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.
MeSH terms
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Animals
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Anthracyclines / chemistry
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Anthracyclines / isolation & purification
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Anthracyclines / pharmacology
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / isolation & purification*
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Antibiotics, Antineoplastic / pharmacology
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Carcinoma, Ehrlich Tumor / pathology
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Drug Screening Assays, Antitumor
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Female
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Fermentation
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Gram-Positive Bacteria / drug effects
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Humans
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology
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Lethal Dose 50
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry
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Mice
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Molecular Structure
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Neoplasm Transplantation
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Soil Microbiology
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Streptomyces / chemistry*
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Streptomyces / classification
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Streptomyces / growth & development
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Tumor Cells, Cultured
Substances
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Anthracyclines
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Antibiotics, Antineoplastic
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BE 19412A
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BE 19412B
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Isoquinolines