A new antitumor antibiotic, BE-19412A, produced by a streptomycete

J Antibiot (Tokyo). 1998 Oct;51(10):908-14. doi: 10.7164/antibiotics.51.908.

Abstract

A new antitumor substance, designated BE-19412A, was isolated from the culture broth of Streptomyces sp. A19412. The active principle was extracted from the mycelium by methanol and purified by Silica gel and Sephadex LH-20 column chromatographies. BE-19412B was prepared by methylation of BE-19412A. BE-19412A and B exhibited cytotoxic activity against murine and human tumor cell lines. BE-19412A prolonged the survival of CDF1 mice bearing i.p. implanted Ehrlich carcinoma cells.

MeSH terms

  • Animals
  • Anthracyclines / chemistry
  • Anthracyclines / isolation & purification
  • Anthracyclines / pharmacology
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Carcinoma, Ehrlich Tumor / pathology
  • Drug Screening Assays, Antitumor
  • Female
  • Fermentation
  • Gram-Positive Bacteria / drug effects
  • Humans
  • Isoquinolines / chemistry
  • Isoquinolines / isolation & purification
  • Isoquinolines / pharmacology
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy / methods
  • Mass Spectrometry
  • Mice
  • Molecular Structure
  • Neoplasm Transplantation
  • Soil Microbiology
  • Streptomyces / chemistry*
  • Streptomyces / classification
  • Streptomyces / growth & development
  • Tumor Cells, Cultured

Substances

  • Anthracyclines
  • Antibiotics, Antineoplastic
  • BE 19412A
  • BE 19412B
  • Isoquinolines