Abstract
Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Autoantibodies / pharmacology
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Cell Line
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Fluorescent Antibody Technique
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G(M1) Ganglioside / metabolism
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Humans
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Mice
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Miller Fisher Syndrome / immunology
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Motor Neurons / drug effects
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Motor Neurons / metabolism*
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Myasthenia Gravis / immunology
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Peripheral Nervous System Diseases / immunology
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Polyradiculoneuropathy / immunology
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Sodium / metabolism
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Sodium Channels / drug effects
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Sodium Channels / metabolism*
Substances
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Autoantibodies
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Sodium Channels
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G(M1) Ganglioside
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Sodium