Immune-mediated peripheral neuropathies and voltage-gated sodiums channels

Muscle Nerve. 1999 Jan;22(1):108-10. doi: 10.1002/(sici)1097-4598(199901)22:1<108::aid-mus16>3.0.co;2-i.

Abstract

Antibodies to GM1 ganglioside are found in some patients with the Guillain-Barré syndrome and multifocal motor neuropathy, and may alter neuronal excitability. We measured voltage-gated sodium channel (VGSC) function by 22Na+ influx in a motor neuronal cell line (NSC19) in which we demonstrated GM1 ganglioside and tetrodotoxin-sensitive VGSC function. We were unable to detect any effect of peripheral neuropathy plasmas, with or without complement, on VGSC function in NSC19 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoantibodies / pharmacology
  • Cell Line
  • Fluorescent Antibody Technique
  • G(M1) Ganglioside / metabolism
  • Humans
  • Mice
  • Miller Fisher Syndrome / immunology
  • Motor Neurons / drug effects
  • Motor Neurons / metabolism*
  • Myasthenia Gravis / immunology
  • Peripheral Nervous System Diseases / immunology
  • Polyradiculoneuropathy / immunology
  • Sodium / metabolism
  • Sodium Channels / drug effects
  • Sodium Channels / metabolism*

Substances

  • Autoantibodies
  • Sodium Channels
  • G(M1) Ganglioside
  • Sodium