Studies of structure activity relationship of flavonoids for the anti-allergic actions

Arch Pharm Res. 1998 Aug;21(4):478-80. doi: 10.1007/BF02974647.

Abstract

The structure activity relationship of flavonoids for anti-allergic actions was studied by determining the IC50 values for the degranulation. The hexosaminidase release from RBL-2H3 cells (degranulation marker) was employed as an estimate for the anti-allergic actions. Among 22 flavonoid compounds tested, luteolin, apigenin, diosmetin, fisetin, and quercetin were found to be most active with IC50 values less than 10 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Allergic Agents / chemistry*
  • Anti-Allergic Agents / pharmacology
  • Catechin / pharmacology
  • Cell Line
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology*
  • Flavonols
  • Isoflavones / pharmacology
  • Molecular Structure
  • Rats
  • Structure-Activity Relationship
  • beta-N-Acetylhexosaminidases / metabolism

Substances

  • Anti-Allergic Agents
  • Flavonoids
  • Flavonols
  • Isoflavones
  • Catechin
  • beta-N-Acetylhexosaminidases