Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2743-6. doi: 10.1016/s0960-894x(98)00481-8.

Abstract

In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rod-shaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chemical Phenomena
  • Chemistry, Physical
  • Electric Conductivity
  • Ion Channel Gating / physiology
  • Ion Channels / chemistry*
  • Ion Channels / physiology*
  • Lipid Bilayers / chemistry*
  • Molecular Conformation
  • Polymers / chemistry
  • Sugar Alcohols / chemistry*

Substances

  • Ion Channels
  • Lipid Bilayers
  • Polymers
  • Sugar Alcohols