Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation

P E Thompson; D L Steer; M I Aguilar; M T Hearn

doi:10.1016/s0960-894x(98)00493-4

Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation

Bioorg Med Chem Lett. 1998 Oct 6;8(19):2699-704. doi: 10.1016/s0960-894x(98)00493-4.

Authors

P E Thompson¹, D L Steer, M I Aguilar, M T Hearn

Affiliation

¹ Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia. Phil.Thompson@boxhill.med.monash.edu.au

PMID: 9873606
DOI: 10.1016/s0960-894x(98)00493-4

Abstract

Novel tropane (azabicycloheptane) and azabicyclohexane containing amino acids have been prepared and incorporated into analogues of reported inhibitors of platelet aggregation. The influence of these central constraints upon biological activity suggest their utility in peptide structure function studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acids / chemistry*
Amino Acids / pharmacology*
Humans
Peptides / chemical synthesis
Peptides / chemistry*
Peptides / pharmacology*
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / chemical synthesis
Platelet Aggregation Inhibitors / chemistry*
Platelet Aggregation Inhibitors / pharmacology*
Structure-Activity Relationship
Tropanes / chemistry*
Tropanes / pharmacology*

Substances

Amino Acids
Peptides
Platelet Aggregation Inhibitors
Tropanes