Identification of N2-(1-carboxymethyl)guanine (CMG) as a guanine advanced glycation end product

Bioorg Med Chem Lett. 1998 Aug 18;8(16):2109-10. doi: 10.1016/s0960-894x(98)00398-9.

Abstract

The reaction of D-glucose with 9-methylguanine produces N2-fructosyl-9-methylguanine, which undergoes oxidation to produce N2-(1-carboxymethyl)-9-methylguanine as a major adduct.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glucose / chemistry*
  • Glycation End Products, Advanced / analysis
  • Glycation End Products, Advanced / chemistry*
  • Guanine / analogs & derivatives*
  • Guanine / chemistry
  • Indicators and Reagents
  • Molecular Structure
  • Oxidation-Reduction

Substances

  • Glycation End Products, Advanced
  • Indicators and Reagents
  • N(2)-(1-carboxymethyl)guanine
  • 9-methylguanine
  • Guanine
  • Glucose