Inhibition of lipid peroxidation mediated by indolizines

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1829-32. doi: 10.1016/s0960-894x(98)00313-8.

Abstract

Esters, ethers, carbonates and carbamates of 1-indolizinols and azaindolizinols exhibit a profound inhibition of lipid peroxidation in vitro. The antioxidants were prepared by cyclization of pyridines and diazines with diphenylcyclopropenone followed by introduction of the O-substituent.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Indolizines / chemistry
  • Indolizines / pharmacology*
  • Lipid Peroxidation / drug effects*
  • Oxidation-Reduction

Substances

  • Antioxidants
  • Indolizines