Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

D Subrahmanyam; B Renuka; C V Rao; P S Sagar; D S Deevi; J M Babu; K Vyas

doi:10.1016/s0960-894x(98)00232-7

Novel D-ring analogues of podophyllotoxin as potent anti-cancer agents

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1391-6. doi: 10.1016/s0960-894x(98)00232-7.

Authors

D Subrahmanyam¹, B Renuka, C V Rao, P S Sagar, D S Deevi, J M Babu, K Vyas

Affiliation

¹ Natural Products Division, Dr. Reddy's Research Foundation, Miyapur, Hyderabad, India.

PMID: 9871772
DOI: 10.1016/s0960-894x(98)00232-7

Abstract

Several D-ring modified analogues of podophyllotoxin were prepared viz semi-synthesis starting from naturally occurring podophyllotoxin and determined their in vitro anti-cancer activity. Most of the analogues have shown good activity towards human cancer cell lines.

MeSH terms

Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / pharmacology*
Drug Screening Assays, Antitumor
Humans
Podophyllotoxin / analogs & derivatives*
Podophyllotoxin / chemical synthesis
Podophyllotoxin / pharmacology*
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Podophyllotoxin