Abstract
The syntheses of several heparin-like glycoconjugates (i.e., 16a-f) containing identical AT III binding domains (ABD) and spacers but different thrombin binding domains (TBDs) are described. Biological activities of conjugates 16a-f indicate that the thrombin inhibitory activity is mainly determined by the charge density of the TBD moiety.
MeSH terms
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Angiotensin III / metabolism
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Binding Sites
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Carbohydrate Conformation
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Carbohydrate Sequence
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Dermatan Sulfate / chemistry
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Drug Design
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Glycoconjugates / chemical synthesis*
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Glycoconjugates / chemistry
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Glycoconjugates / pharmacology*
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Heparin / analogs & derivatives*
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Heparin / pharmacology*
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Models, Molecular
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Molecular Sequence Data
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Oligosaccharides / chemical synthesis*
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Oligosaccharides / chemistry
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Oligosaccharides / pharmacology
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Structure-Activity Relationship
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Thrombin / metabolism*
Substances
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Glycoconjugates
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Oligosaccharides
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Angiotensin III
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Dermatan Sulfate
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Heparin
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Thrombin