Homologated aza analogs of arabinose as antimycobacterial agents

Bioorg Med Chem Lett. 1998 Feb 3;8(3):237-42. doi: 10.1016/s0960-894x(98)00017-1.

Abstract

A series of hydrolytically-stable aza analogs of arabinofuranose was prepared and evaluated against Mycobacterium tuberculosis and M. avium. The compounds were designed to mimic the putative arabinose donor involved in biogenesis of the essential cell wall polysaccharide, arabinogalactan. Though most compounds displayed little activity in cell culture, one compound showed significant activity in infected macrophage models.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Arabinose / chemistry
  • Arabinose / pharmacology*
  • Cell Line
  • Humans
  • Macrophages / microbiology
  • Mice
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium avium Complex / drug effects*
  • Mycobacterium avium Complex / isolation & purification
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Arabinose