Synthesis and in vitro cytotoxicity of 3- or 4-dialkylaminomethyl-1-azaanthraquinones

Arch Pharm Res. 1998 Dec;21(6):749-52. doi: 10.1007/BF02976770.

Abstract

Six 3-dialkylaminomethyl-1-azaanthraquinones and five 4-dialkylaminomethyl-1-azaanthraquinones were synthesized and evaluated in vitro cytotoxicity against four human cancer cell lines. The compounds retained much of their cytotoxic activity against the multi-drug-resistant cell line (KB-V-1) as shown by resistance index.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones / chemical synthesis
  • Anthraquinones / therapeutic use*
  • Anthraquinones / toxicity
  • Antineoplastic Agents / therapeutic use*
  • Aza Compounds / chemical synthesis
  • Aza Compounds / therapeutic use*
  • Aza Compounds / toxicity
  • Drug Evaluation
  • Humans
  • Tumor Cells, Cultured

Substances

  • Anthraquinones
  • Antineoplastic Agents
  • Aza Compounds