Macromolecular cytosolic delivery: cell membranes as the primary obstacle

Arch Pharm Res. 1998 Dec;21(6):621-8. doi: 10.1007/BF02976747.

Abstract

The "evolution" of a thing, a custom, an organ is thus by no means its progressus toward a goal, even less a logical progressus by the shortest route and with the least expenditure of force, but a succession of more or less profound, mutually independent processes of subduing, plus the resistances they encounter, the attempts at transformation for the purpose of defense and reaction, and the results of successful counteractions. The form is fluid, but the "meaning" is even more so.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Bacteria / metabolism
  • Cell Membrane / metabolism*
  • Cytosol / metabolism*
  • Drug Delivery Systems*
  • Gene Targeting
  • Genetic Vectors
  • Humans
  • Macromolecular Substances
  • Viruses / metabolism

Substances

  • Macromolecular Substances