Nasopharyngeal carcinoma (NPC) is an intriguing disease that shows a distinct geographical distribution with well-defined, high-risk ethnic groups. This neoplasm exhibits strong associations with the Epstein-Barr virus, dietary and genetic factors. Radiation therapy is the mainstay of treatment and imaging plays a central role in tumor mapping and radiation therapy planning. NPC provides an excellent model for the study of normal and pathological anatomy of the skull base. It also provides an excellent model in the study of consequences of radiation therapy.