Synthesis and biological evaluation of 1,2,5-oxadiazole N-oxide derivatives as hypoxia-selective cytotoxins

Pharmazie. 1998 Nov;53(11):758-64.

Abstract

Synthesis and biological evaluation of new 1,2,5-oxadiazole N-oxide derivatives with potential cytotoxic effects are described. From the series of compounds tested, compounds 2 and 6 proved to be very active, although non-selective.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Hypoxia / drug effects
  • Cricetinae
  • Cricetulus
  • Cyclic N-Oxides / chemical synthesis*
  • Cyclic N-Oxides / chemistry
  • Cyclic N-Oxides / pharmacology
  • Drug Screening Assays, Antitumor
  • Models, Molecular
  • Oxadiazoles / chemical synthesis*
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology
  • Tumor Cells, Cultured
  • X-Ray Diffraction

Substances

  • 3-chloromethyl-4-phenyl-1,2,5-oxadiazole-2-oxide
  • 4-phenyl-1,2,5-oxadiazole-3-carboxaldehyde-2-oxide
  • Antineoplastic Agents
  • Cyclic N-Oxides
  • Oxadiazoles