Antioxidant activity of aminoethylcysteine ketimine decarboxylated dimer on copper-induced LDL oxidation

Biochem Mol Biol Int. 1998 Nov;46(4):829-37. doi: 10.1080/15216549800204372.

Abstract

Aminoethylcysteine ketimine decarboxylated dimer (AECK-DD), a member of a family of natural cyclic sulfur-containing aminoacids, recently detected in biological samples, protects low density lipoprotein (LDL) against copper-mediated oxidation, as assessed by monitoring the kinetics of conjugated diene formation, thiobarbituric acid-reactive substances production and LDL-tryptophan fluorescence quenching. Moreover, AECK-DD exerts a protective effect also against metal-independent, peroxyl radical-induced lipoprotein oxidation. It is of note that the concentrations exerting a protective effect against LDL oxidation are similar to those found in biological samples.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids, Sulfur / chemistry
  • Amino Acids, Sulfur / pharmacology*
  • Antioxidants / pharmacology*
  • Apolipoprotein B-100
  • Apolipoproteins B / chemistry
  • Copper / pharmacology*
  • Dimerization
  • Humans
  • In Vitro Techniques
  • Lipid Peroxidation
  • Lipoproteins, LDL / metabolism*
  • Thiobarbituric Acid Reactive Substances / metabolism
  • Tryptophan / chemistry

Substances

  • Amino Acids, Sulfur
  • Antioxidants
  • Apolipoprotein B-100
  • Apolipoproteins B
  • Lipoproteins, LDL
  • Thiobarbituric Acid Reactive Substances
  • thialysine ketimine
  • Copper
  • Tryptophan