The authors report a case of benign solitary cecal ulcer, occurred recently to their observation and diagnosed during operation. The patient was undergo an operation of right hemicolectomy. The preoperative diagnosis of lesion kind and its localization is difficult because it's a rare disease as well as literature reports; in fact the benign solitary colon ulcer can be differentiated with difficult from a perforated appendicitis, an inflammatory disease and a colon carcinoma. The authors discuss about probable etiologic factors, clinical features and surgical treatment.