Anti-inflammatory drugs interacting with Zn(II), Cd(II) and Pt(II) metal ions

J Inorg Biochem. 1998 Sep;71(3-4):171-9. doi: 10.1016/s0162-0134(98)10051-x.

Abstract

Complexes of Zn(II), Cd(II) and Pt(II) metal ions with the anti-inflammatory drugs, 1-methyl-5-(p-toluoyl)-1H-pyrrole-2-acetic acid (Tolmetin), alpha-methyl-4-(2-methylpropyl)benzeneacetic acid (Ibuprofen), 6-methoxy-alpha-methylnaphthalene-2-acetic acid (Naproxen) and 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (indomethacin) have been synthesized and characterized. In the structurally characterized Cd(naproxen)2 complex the anti-inflammatory drugs acts as bidentate chelate ligand coordinatively bound to metal ions through the deprotonated carboxylate group. Crystal data for 1: [C32H26O8Cd], orthorhombic, space group P22(1)2(1), a = 5.693(2) (A), b = 8.760(3) (A), c = 30.74(1) (A), V = 1533(1) A3, Z = 2. Antibacterial and growth inhibitory activity is higher than that of the parent ligands or the platinum(II) diamine compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Bacteria / drug effects
  • Cadmium / pharmacology*
  • Cations, Divalent
  • Cell Division / drug effects
  • Cell Line
  • Chelating Agents
  • Cricetinae
  • Crystallography, X-Ray
  • Drug Interactions
  • Humans
  • Ibuprofen / chemistry
  • Ibuprofen / pharmacology
  • In Vitro Techniques
  • Indomethacin / chemistry
  • Indomethacin / pharmacology
  • Ligands
  • Models, Molecular
  • Platinum / pharmacology*
  • Structure-Activity Relationship
  • Tolmetin / chemistry
  • Tolmetin / pharmacology
  • Tumor Cells, Cultured
  • Zinc / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Cations, Divalent
  • Chelating Agents
  • Ligands
  • Cadmium
  • Platinum
  • Tolmetin
  • Zinc
  • Ibuprofen
  • Indomethacin