[Insulin-dependent diabetes in Senegal: HLA-DR combinations according to age of onset and sex]

A Cisse; M Chauffert; S N Diop; D Chevenne; E H Sidibe; S Michel; A M Sow; F Trivin

[Insulin-dependent diabetes in Senegal: HLA-DR combinations according to age of onset and sex]

Dakar Med. 1998;43(1):54-6.

[Article in French]

Authors

A Cisse¹, M Chauffert, S N Diop, D Chevenne, E H Sidibe, S Michel, A M Sow, F Trivin

Affiliation

¹ Laboratoire de Physique Pharmaceutique, Faculté de Médecine, de Pharmacie et d'Odontostomatologie, Université Cheikh Anta DIOP, Dakar, Sénégal.

PMID: 9827157

Abstract

In insulin-dependent diabetes mellitus, HLA-DR markers are involved, namely DR3, DR4 and DR9 alleles, among black senegalese populations. Studying the different associations of these alleles showed a strong predisposition to insulin-dependent diabetes mellitus with DR3/4 (p > 10(-2); OR = 13.6); DR4/9 (p < 10(-2); OR = 8.32) and DR9/9 (p < 0.05; OR = 7.78). And then it was observed a tendency to an inverse relationship of DR3/4 frequency with age of onset in male patients.

MeSH terms

Adolescent
Adult
Age of Onset
Alleles
Autoimmune Diseases / epidemiology
Autoimmune Diseases / genetics*
Autoimmune Diseases / immunology
Black People / genetics
Child
Child, Preschool
Diabetes Mellitus, Type 1 / epidemiology
Diabetes Mellitus, Type 1 / genetics*
Diabetes Mellitus, Type 1 / immunology
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DR Antigens / genetics*
Humans
Male

Substances

HLA-DR Antigens