Activation of histone gene transcription by nonhistone chromosomal phosphoproteins

J A Thompson; J L Stein; L J Kleinsmith; G S Stein

doi:10.1126/science.982025

Activation of histone gene transcription by nonhistone chromosomal phosphoproteins

Science. 1976 Oct 22;194(4263):428-31. doi: 10.1126/science.982025.

Authors

J A Thompson, J L Stein, L J Kleinsmith, G S Stein

PMID: 982025
DOI: 10.1126/science.982025

Abstract

Hybridization analysis of RNA transcripts from HeLa S3 cell chromatin to histone complementary DNA indicates that a chromosomal phosphoprotein fraction activates transcription of histone messenger RNA sequences in vitro with chromatin from a phase in the cell cycle when histone genes are normally silent.

MeSH terms

Cell Division
Chromatin / metabolism*
Chromosomal Proteins, Non-Histone / pharmacology*
Genes
HeLa Cells
Histones / biosynthesis*
Phosphoproteins / pharmacology
RNA, Messenger / biosynthesis*
Transcription, Genetic / drug effects*

Substances

Chromatin
Chromosomal Proteins, Non-Histone
Histones
Phosphoproteins
RNA, Messenger