Abstract
Surfactant protein D (SP-D) is a member of the family of collagenous host defense lectins, designated collectins. There is increasing evidence that SP-D, like SP-A, is an important component of the innate immune response to microbial challenge, and that it may participate in other aspects of immune and inflammatory regulation within the lung. SP-D binds to glycoconjugates and/or lipid moieties expressed by a wide variety of microorganisms and certain other organic particles, in vitro. Although binding may facilitate microbial clearance through aggregation or other direct effects on the organism, SP-D also has the capacity to modulate leukocyte function, and in some circumstances, to enhance their killing of microorganisms.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Bacteria / immunology
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Bacteria / metabolism
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Fungi / immunology
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Fungi / metabolism
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Gene Expression Regulation
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Glycoconjugates / metabolism
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Glycoproteins / chemistry
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Glycoproteins / immunology*
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Glycoproteins / metabolism
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Immunity, Innate
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Lectins / chemistry
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Lectins / immunology*
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Lectins / metabolism
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Models, Molecular
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Phagocytes / immunology
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Protein Binding
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Pulmonary Surfactant-Associated Protein D
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Pulmonary Surfactants / chemistry
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Pulmonary Surfactants / immunology*
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Pulmonary Surfactants / metabolism
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Viruses / immunology
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Viruses / metabolism
Substances
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Glycoconjugates
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Glycoproteins
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Lectins
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Pulmonary Surfactant-Associated Protein D
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Pulmonary Surfactants