The two-exon gene of the human forkhead transcription factor FREAC-2 (FKHL6) is located at 6p25.3

Genomics. 1998 Nov 1;53(3):387-90. doi: 10.1006/geno.1998.5451.

Abstract

The gene for the human transcription factor forkhead related activator 2 (FREAC-2; HGMW-approved symbol FKHL6) has been characterized and found to consist of two exons separated by an intron of 3.6 kb. The first exon encodes the forkhead DNA-binding domain and one of the transcriptional activation domains, AD2. The second exon contains the coding sequence corresponding to the C-terminal activation domain AD1. The full-length FREAC-2 protein is predicted to be 444 amino acids, which adds 39 amino acids to the previously published partial cDNA sequence. A 2-kb CG island is centered around the 5' end of the FREAC-2 gene. Fluorescence in situ hybridization was used to localize the human FREAC-2 gene to chromosomal position 6p24-p25, and the localization was further refined by radiation hybrid mapping to 6p25.3.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites / genetics
  • Chromosome Mapping
  • Chromosomes, Human, Pair 6 / genetics*
  • Consensus Sequence
  • CpG Islands
  • DNA Primers / genetics
  • DNA, Complementary / genetics
  • DNA-Binding Proteins / genetics*
  • Exons
  • Forkhead Transcription Factors
  • Humans
  • Hybrid Cells
  • In Situ Hybridization, Fluorescence
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Trans-Activators / genetics*

Substances

  • DNA Primers
  • DNA, Complementary
  • DNA-Binding Proteins
  • FOXF2 protein, human
  • Forkhead Transcription Factors
  • LUN protein, vertebrate
  • Trans-Activators

Associated data

  • GENBANK/AF084938
  • GENBANK/AF084939