Risk of recurrent spontaneous abortion, cigarette smoking, and genetic polymorphisms in NAT2 and GSTM1

Epidemiology. 1998 Nov;9(6):666-8.

Abstract

Maternal smoking increases the risk of spontaneous abortion. Polymorphic N-acetyltransferase (NAT2) and glutathione S-transferase (GSTM1) affect metabolism of some mutagens found in tobacco smoke. Genotypes and smoking were studied in women with at least two spontaneous abortions (N = 32) and those with at least two livebirths (N = 179). Smoking slightly increased risk (odds ratio = 1.3; 95% confidence interval = 0.6-2.9), but NAT2 and GSTM1 did not. NAT2 or GSTM1 polymorphisms did not appreciably modify smoking-related risk.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abortion, Spontaneous / epidemiology*
  • Abortion, Spontaneous / etiology
  • Adult
  • Aged
  • Arylamine N-Acetyltransferase / genetics*
  • Female
  • Glutathione Transferase / genetics*
  • Humans
  • Middle Aged
  • Molecular Epidemiology
  • Mutagens / metabolism
  • Polymorphism, Genetic*
  • Pregnancy
  • Retrospective Studies
  • Risk Factors
  • Smoking / adverse effects*

Substances

  • Mutagens
  • Arylamine N-Acetyltransferase
  • Glutathione Transferase