Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees

Vaccine. 1998 Nov;16(19):1836-41. doi: 10.1016/s0264-410x(98)00178-9.

Abstract

A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Vaccines / adverse effects
  • AIDS Vaccines / immunology*
  • AIDS Vaccines / therapeutic use
  • Animals
  • DNA, Viral / genetics
  • DNA, Viral / immunology*
  • Disease Models, Animal
  • Female
  • HIV Antibodies / blood
  • HIV Infections / blood
  • HIV Infections / prevention & control
  • HIV-1 / genetics*
  • HIV-1 / immunology*
  • Lymphocyte Subsets / immunology
  • Male
  • Pan troglodytes
  • Pregnancy
  • Vaccines, DNA / adverse effects
  • Vaccines, DNA / immunology*
  • Vaccines, DNA / therapeutic use

Substances

  • AIDS Vaccines
  • DNA, Viral
  • HIV Antibodies
  • Vaccines, DNA