Cholinergic excitation induces activity-dependent electrophysiological and transcriptional responses in hippocampal slices

A Friedman; D Kaufer; L Pavlovsky; H Soreq

doi:10.1016/s0928-4257(98)80042-9

Cholinergic excitation induces activity-dependent electrophysiological and transcriptional responses in hippocampal slices

J Physiol Paris. 1998 Jun-Aug;92(3-4):329-35. doi: 10.1016/s0928-4257(98)80042-9.

Authors

A Friedman¹, D Kaufer, L Pavlovsky, H Soreq

Affiliation

¹ Department of Physiology, Faculty of Health Sciences, Ben Gurion University, Beersheva, Israel.

PMID: 9789832
DOI: 10.1016/s0928-4257(98)80042-9

Abstract

To explore the correlations between short-term neurophysiological events initiated by over-activation of acetylcholine receptors, and long-lasting changes in brain function, we combined electrophysiology and PCR-based measurements in hippocampal slices or live mice subjected to stress or drug-induced cholinergic activation. Our findings reveal a common cascade of neuronal events resulting in delayed suppression of cholinergic transmission.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / pharmacology*
Hippocampus / drug effects*
Hippocampus / metabolism
In Vitro Techniques
Mice
Receptors, Muscarinic / physiology
Reverse Transcriptase Polymerase Chain Reaction
Stress, Physiological / metabolism
Transcription, Genetic / drug effects*

Substances

Cholinesterase Inhibitors
Receptors, Muscarinic