Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor

R Carrizo; M E Sosa; L S Favier; F Penna; E Guerreiro; O S Giordano; C E Tonn

doi:10.1021/np9800248

Growth-inhibitory activities of benzofuran and chromene derivatives toward Tenebrio molitor

J Nat Prod. 1998 Oct;61(10):1209-11. doi: 10.1021/np9800248.

Authors

R Carrizo¹, M E Sosa, L S Favier, F Penna, E Guerreiro, O S Giordano, C E Tonn

Affiliation

¹ Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700, San Luis, Argentina.

PMID: 9784153
DOI: 10.1021/np9800248

Abstract

Growth-inhibitory activities of selected natural benzofurans (4-9), trans-cinnamic acid derivatives (10-13), chromene compounds (14 and 16), and some semisynthetic derivatives were determined in last instar larvae of Tenebrio molitor via topical administration in Me2CO. The most inhibitory of the tested compounds were 3-gamma, gamma-dimethylallyl-p-coumaric acid (10) and the benzofuran derivative 12-(p-cumaroyloxy)-tremetone (5), the former compound acting on the pupae and the latter on the last instar larvae. Several developmental deficiencies were observed, and some structure-activity relationships are discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzofurans* / isolation & purification
Chromans* / isolation & purification
Growth Inhibitors*
Insecticides*
Plants / chemistry*
Tenebrio

Substances

Benzofurans
Chromans
Growth Inhibitors
Insecticides