Abstract
A patient presented with a peripheral neuropathy and was found to have Waldenstrom's macroglobulinemia with high serum titers of antibodies to myelin-associated glycoprotein. He developed parkinsonism that was poorly responsive to levodopa. He failed conventional therapy and was treated with autologous bone marrow transplantation, which resulted in improvement of the neuropathy but not his parkinsonism. Critical cytoreduction in the B-cell clone may be necessary for improvement of the neuropathy of Waldenstrom's macroglobulinemia.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Monoclonal / blood
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Bone Marrow Transplantation*
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Dihydroxyphenylalanine / analogs & derivatives
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Fluorine Radioisotopes
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Fluorodeoxyglucose F18
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Humans
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Immunoglobulin M / blood
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Male
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Middle Aged
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Myelin-Associated Glycoprotein / immunology
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Neural Conduction
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Parkinson Disease, Secondary / diagnostic imaging
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Parkinson Disease, Secondary / etiology
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Parkinson Disease, Secondary / therapy
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Peripheral Nervous System Diseases / diagnostic imaging*
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Peripheral Nervous System Diseases / etiology*
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Peripheral Nervous System Diseases / therapy
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Tomography, Emission-Computed
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Waldenstrom Macroglobulinemia / complications*
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Waldenstrom Macroglobulinemia / immunology
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Waldenstrom Macroglobulinemia / therapy*
Substances
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Antibodies, Monoclonal
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Fluorine Radioisotopes
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Immunoglobulin M
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Myelin-Associated Glycoprotein
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Fluorodeoxyglucose F18
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fluorodopa F 18
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Dihydroxyphenylalanine