Mallory-Weiss syndrome is one of the cause of upper gastrointestinal hemorrhage, which an abrupt rise in abdominal pressure due to nausea or vomiting induces a tear near the esophagogastric mucosal junction. Mallory-Weiss syndrome represents about 3-15% of all cases of upper gastrointestinal hemorrhage. Mallory-Weiss tear is mainly located on the cardia part of the stomach side and spanning across the esophagogastric mucosal junction, only in esophageal side is rarely seen. Hemorrhage frequently ceases spontaneously. When endoscopic findings reveal persistent hemorrhage, endoscopic hemostatic technique using heater probe thermocoagulation or hemoclipping is necessary. After endoscopic hemostasis, fasting and inhibitors of acid secretion (H2-receptor antagonists or proton pump inhibitors) are recommended.