Abstract
Prostatic carcinoma is the most common type of male cancer found in the Western world and its distant metastasis becomes a life threatening event in tumour bearing patients. However, the biology of prostate cancer and metastasis is poorly understood. We review the progress made in the last decade on the molecular and cellular biology of cell-cell adhesion molecules in the invasion and progression of prostate cancer, with emphasis being placed on E-cadherin and its associated molecules.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cadherins / chemistry
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Cadherins / genetics
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Cadherins / physiology*
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Cell Adhesion
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Cell Adhesion Molecules / physiology
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Disease Progression
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Female
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Humans
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Immunoglobulins / physiology
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Incidence
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Integrins / physiology
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Male
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Neoplasm Invasiveness
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Prostatic Neoplasms / epidemiology
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Prostatic Neoplasms / pathology*
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Prostatic Neoplasms / physiopathology*
Substances
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Cadherins
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Cell Adhesion Molecules
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Immunoglobulins
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Integrins