Size control: cell proliferation does not equal growth

Curr Biol. 1998 Sep 24;8(19):R687-9. doi: 10.1016/s0960-9822(98)70436-1.

Abstract

Division subdivides mass without increasing it. So one should not expect that an increase in cell division would make an organism bigger. Both classic and recent experiments confirm this simple rationale: altering proliferation produces normally sized body structures with either especially small or exceptionally large cells.

Publication types

  • Review

MeSH terms

  • Animals
  • CDC2 Protein Kinase / physiology
  • Carrier Proteins*
  • Cell Cycle Proteins / physiology
  • Cell Division*
  • Cell Size
  • DNA-Binding Proteins*
  • Drosophila Proteins*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / growth & development
  • E2F Transcription Factors
  • Embryo, Nonmammalian
  • Growth / physiology*
  • Insect Proteins / physiology
  • Phosphoprotein Phosphatases / physiology
  • Pupa
  • Retinoblastoma-Binding Protein 1
  • Trans-Activators*
  • Transcription Factors / deficiency
  • Transcription Factors / physiology
  • Wings, Animal / cytology
  • Wings, Animal / embryology
  • Wings, Animal / growth & development
  • cdc25 Phosphatases

Substances

  • Carrier Proteins
  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Dp transcription factor, Drosophila
  • Drosophila Proteins
  • E2F Transcription Factors
  • Insect Proteins
  • Retinoblastoma-Binding Protein 1
  • Trans-Activators
  • Transcription Factors
  • CDC2 Protein Kinase
  • Phosphoprotein Phosphatases
  • cdc25 Phosphatases