Influence of "Polarizing" infusions on anthiarrhythmic effects of beta-blockers

G Ital Cardiol. 1976;6(4):620-7.

Abstract

The antiarrhythmic effect of practolol (0.30 mg/kg) was studied in 25 patients pretreated with infusion of glucose-insulin (GI) solution. GI solution showed an antiarrhythmic effect either after or before the beta-blocker with pH in normal range or compensated metabolic acidosis. GI infusion produced a metabolic acidosis and an arrhythmogenic effect in some cases. Practolol had no antiarrhythmic effect in patients with VPB and GI infusion raised metabolic acidosis.

MeSH terms

  • Acidosis / chemically induced
  • Adolescent
  • Adult
  • Aged
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / drug therapy*
  • Drug Combinations
  • Drug Evaluation
  • Drug Therapy, Combination
  • Female
  • Glucose / administration & dosage
  • Glucose / adverse effects
  • Glucose / therapeutic use*
  • Humans
  • Infusions, Parenteral
  • Injections, Intravenous
  • Insulin / administration & dosage
  • Insulin / adverse effects
  • Insulin / therapeutic use*
  • Male
  • Middle Aged
  • Practolol / administration & dosage
  • Practolol / therapeutic use*

Substances

  • Drug Combinations
  • Insulin
  • Glucose
  • Practolol