Abstract
The antiarrhythmic effect of practolol (0.30 mg/kg) was studied in 25 patients pretreated with infusion of glucose-insulin (GI) solution. GI solution showed an antiarrhythmic effect either after or before the beta-blocker with pH in normal range or compensated metabolic acidosis. GI infusion produced a metabolic acidosis and an arrhythmogenic effect in some cases. Practolol had no antiarrhythmic effect in patients with VPB and GI infusion raised metabolic acidosis.
MeSH terms
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Acidosis / chemically induced
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Adolescent
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Adult
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Aged
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / drug therapy*
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Drug Combinations
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Drug Evaluation
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Drug Therapy, Combination
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Female
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Glucose / administration & dosage
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Glucose / adverse effects
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Glucose / therapeutic use*
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Humans
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Infusions, Parenteral
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Injections, Intravenous
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Insulin / administration & dosage
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Insulin / adverse effects
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Insulin / therapeutic use*
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Male
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Middle Aged
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Practolol / administration & dosage
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Practolol / therapeutic use*
Substances
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Drug Combinations
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Insulin
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Glucose
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Practolol