Costimulation of naive CD8(+) lymphocytes induces CD4 expression and allows human immunodeficiency virus type 1 infection

J Virol. 1998 Nov;72(11):9054-60. doi: 10.1128/JVI.72.11.9054-9060.1998.

Abstract

Human immunodeficiency virus type 1 (HIV-1) infection requires cell surface expression of CD4. Costimulation of CD8(+)/CD4(-) T lymphocytes by anti-CD3 and anti-CD28 antibodies or by allogeneic dendritic cells induced expression of CD4 and rendered these CD8 cells susceptible to HIV-1 infection. Naive CD45RA+ cells responded with greater expression of CD4 than did CD45RO+ cells. CD8(+) lymphocytes derived from fetal or newborn sources exhibited a greater tendency to express CD4, consistent with their naive states. This mechanism of infection suggests HIV-induced perturbation of the CD8 arm of the immune response and could explain the generally rapid disease progression seen in HIV-infected children.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • CD4 Antigens / metabolism*
  • CD8-Positive T-Lymphocytes / immunology*
  • Cells, Cultured
  • Child
  • Fetus
  • HIV Infections / etiology*
  • HIV Infections / immunology*
  • HIV-1 / pathogenicity*
  • Humans
  • In Vitro Techniques
  • Infant, Newborn
  • Leukocyte Common Antigens / metabolism
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Phenotype
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Receptors, HIV / metabolism
  • T-Lymphocyte Subsets / immunology

Substances

  • CD4 Antigens
  • Receptors, HIV
  • Leukocyte Common Antigens
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1