Objective: To compare the effectiveness of three methods of sperm preparation for IUI during superovulation of infertile women.
Design: Randomized assignment of one of three sperm preparation methods.
Setting: University infertility practice.
Patient(s): Infertile couples undergoing superovulation and IUI.
Intervention(s): The method of preparation of sperm for IUI during superovulation was assigned randomly to double centrifugation, multiple-tube swim-up, or Percoll density gradient.
Main outcome measure(s): Total number and percent recovery of motile sperm, percent of recovered sperm with normal morphology, and cycle fecundity.
Result(s): No method of sperm preparation provided better cycle fecundity than the others despite differences in sperm recovery.
Conclusion(s): Double centrifugation, multiple-tube swim-up, and Percoll density gradient sperm preparation for IUI yield similar cycle fecundity rates.