Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

A A Vink; V Shreedhar; L Roza; J Krutmann; M L Kripke

doi:10.1016/S1011-1344(98)00128-6

Cellular target of UVB-induced DNA damage resulting in local suppression of contact hypersensitivity

J Photochem Photobiol B. 1998 Jul 10;44(2):107-11. doi: 10.1016/S1011-1344(98)00128-6.

Authors

A A Vink¹, V Shreedhar, L Roza, J Krutmann, M L Kripke

Affiliation

¹ Department of Molecular Toxicology, TNO Nutrition and Food Research Institute, Zeist, Netherlands.

PMID: 9757591
DOI: 10.1016/S1011-1344(98)00128-6

Abstract

Experimental data are reviewed that lend support to the hypothesis that formation of DNA damage is the initiation event of local suppression of contact hypersensitivity (CHS) after exposure to ultraviolet (UV) radiation and that the antigen-presenting cell (APC) is an important target for this DNA damage.

Publication types

Review

MeSH terms

Animals
Cells, Cultured
DNA / radiation effects*
DNA Damage*
Dermatitis, Contact / genetics*
Dermatitis, Contact / immunology
Humans
Immunosuppression Therapy*
Models, Genetic
Models, Immunological
Ultraviolet Rays*

Substances

DNA