A nonlinear explanation of aging-induced changes in heartbeat dynamics

Am J Physiol. 1998 Oct;275(4):H1455-61. doi: 10.1152/ajpheart.1998.275.4.H1455.

Abstract

The possibility of computing a cardiac age on the basis of spectral analysis of healthy individual tachograms was confirmed and facilitated by the use of a nonlinear technique: recurrence quantification analysis. The age of 112 subjects was predicted by this technique in terms of a progressive increase in the deterministic character of the heartbeat. This result confirms the "random-walk" character of the heartbeat as predicted by the terminal dynamics paradigm, thus allowing for a simple and comprehensive model of the effect of aging on cardiac dynamics: as age progresses, heart rate dynamics become increasingly predictable (constrained) on a beat-to-beat basis. This implies a basically stochastic nature of heart rate dynamics, probably reflecting the continuous adjustments to an unpredictable internal environment.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / physiology*
  • Computer Simulation
  • Electrocardiography*
  • Heart Rate / physiology*
  • Humans
  • Middle Aged
  • Reference Values