Abstract
Activation of the opioid receptors by delta-agonist DSLET and by kappa-agonist rimorphin led to a significant inhibition of plaque-forming and rosette-forming cells in the CBA mice. On the other hand, mu-agonist DAGO stimulated the immune response on the 4th and 5th days after immunization with SRBC (5 x 10(8)). Lesion of the hypothalamo-hypophyseal connection prevented immuno-stimulating as well as immuno-depressive effects. The latter seems to be due to an interaction with the serotoninergic system, whereas immuno-stimulating effect involves the dopaminergic system.
MeSH terms
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Animals
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Cyproheptadine / pharmacology
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Dopamine D2 Receptor Antagonists
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Dynorphins / pharmacology
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Endorphins / pharmacology
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Enkephalin, Leucine / analogs & derivatives
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Enkephalin, Leucine / pharmacology
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Enkephalins / pharmacology
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Haloperidol / pharmacology
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Male
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Mice
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Mice, Inbred CBA
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Neuroimmunomodulation / drug effects*
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Neuroimmunomodulation / immunology
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Pituitary Gland / immunology
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Pituitary Gland / physiology
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Receptor, Serotonin, 5-HT2A
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Receptors, Dopamine D2 / immunology
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Receptors, Opioid / agonists*
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Receptors, Opioid / immunology
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Receptors, Opioid, delta / agonists
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Receptors, Opioid, delta / immunology
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Receptors, Opioid, kappa / agonists
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Receptors, Opioid, kappa / immunology
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Receptors, Opioid, mu / agonists
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Receptors, Opioid, mu / immunology
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / immunology
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Spleen / cytology
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Spleen / drug effects
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Spleen / immunology
Substances
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Dopamine D2 Receptor Antagonists
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Endorphins
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Enkephalins
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Receptor, Serotonin, 5-HT2A
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Receptors, Dopamine D2
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Receptors, Opioid
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Receptors, Opioid, delta
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Receptors, Opioid, kappa
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Receptors, Opioid, mu
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Receptors, Serotonin
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Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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Cyproheptadine
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Enkephalin, Leucine
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Dynorphins
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enkephalin, Ser(2), Leu(5), Thr(6)-
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rimorphin
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Haloperidol