Peptidomimetic design

A S Ripka; D H Rich

doi:10.1016/s1367-5931(98)80119-1

Peptidomimetic design

Curr Opin Chem Biol. 1998 Aug;2(4):441-52. doi: 10.1016/s1367-5931(98)80119-1.

Authors

A S Ripka¹, D H Rich

Affiliation

¹ Department of Chemistry and School of Pharmacy, University of Wisconsin-Madison 53706, USA.

PMID: 9736916
DOI: 10.1016/s1367-5931(98)80119-1

Abstract

Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.

Publication types

Review

MeSH terms

Aspartic Acid Endopeptidases / antagonists & inhibitors
Drug Design*
Enzyme Inhibitors* / chemistry
Forecasting
Molecular Mimicry*
Peptides*
Protein Conformation

Substances

Enzyme Inhibitors
Peptides
Aspartic Acid Endopeptidases