Abstract
Epileptic patients on long-term therapy with a single anticonvulsant showed enhanced expression of peripheral benzodiazepine receptors (pBZrs) on neutrophils, monocytes and lymphocytes. N-Formyl-methionyl-leucyl-phenylalanine-induced chemotaxis was significantly impaired in neutrophils from patients on carbamazepine (p < 0.01 vs. controls). Neutrophils from patients on phenytoin had enhanced phorbol myristate acetate-stimulated O-2 production (p < 0. 01 vs. controls) and neutrophils from patients on valproic acid had impaired phagocytosis frequency and Staphylococcus aureus lethality index (p < 0.01 vs. controls). Overexpression of pBZrs on leukocytes may reflect the clinical response to anticonvulsants and may play a role in the immunological effects of some of these drugs.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Anticonvulsants / pharmacology
-
Anticonvulsants / therapeutic use*
-
Carbamazepine / pharmacology
-
Carbamazepine / therapeutic use
-
Epilepsy / drug therapy*
-
Epilepsy / immunology
-
Epilepsy / pathology
-
Female
-
Humans
-
Leukocytes / drug effects
-
Leukocytes / metabolism
-
Leukocytes / physiology*
-
Lymphocytes / drug effects
-
Lymphocytes / physiology
-
Male
-
Middle Aged
-
Neutrophils / drug effects
-
Neutrophils / metabolism
-
Neutrophils / physiology*
-
Phenytoin / pharmacology
-
Phenytoin / therapeutic use
-
Receptors, GABA-A / biosynthesis*
-
Receptors, GABA-A / physiology
-
Valproic Acid / pharmacology
-
Valproic Acid / therapeutic use
Substances
-
Anticonvulsants
-
Receptors, GABA-A
-
Carbamazepine
-
Valproic Acid
-
Phenytoin