BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

K W Cho; I L Blitz

doi:10.1016/s0959-437x(98)80116-0

BMPs, Smads and metalloproteases: extracellular and intracellular modes of negative regulation

Curr Opin Genet Dev. 1998 Aug;8(4):443-9. doi: 10.1016/s0959-437x(98)80116-0.

Authors

K W Cho¹, I L Blitz

Affiliation

¹ Department of Developmental and Cell Biology, University of California, Irvine 92697, USA. kwcho@uci.edu

PMID: 9729721
DOI: 10.1016/s0959-437x(98)80116-0

Abstract

Bone morphogenetic (BMPs), members of the TGF-beta superfamily, have critical functions in many biological contexts. Recent findings in Drosophila and vertebrates suggest that BMP signaling can be modulated extracellularly and intracellularly by the availability of BMP inhibitors and Smads, respectively.

Publication types

Review

MeSH terms

Animals
Bone Morphogenetic Proteins / metabolism*
Metalloendopeptidases / metabolism*
Signal Transduction*
Transforming Growth Factor beta / metabolism*

Substances

Bone Morphogenetic Proteins
Transforming Growth Factor beta
Metalloendopeptidases