A sequential algorithm for the non-linear dual-sorption model of percutaneous drug absorption

Math Biosci. 1998 Aug 15;152(1):87-103. doi: 10.1016/s0025-5564(98)10021-4.

Abstract

A sequential algorithm is developed for the non-linear dual-sorption model developed by Chandrasekaran et al. [1,2] which monitors pharmacokinetic profiles in percutaneous drug absorption. In the experimental study of percutaneous absorption, it is often observed that the lag-time decreases with the increase in the donor concentration when two or more donor concentrations of the same compound are used. The dual-sorption model has sometimes been employed to explain such experimental results. In this paper, it is shown that another feature observed after vehicle removal may also characterize the dual-sorption model. Soon after vehicle removal, the plots of the drug flux versus time become straight lines on a semilogarithmic scale as in the linear model, but the half-life is prolonged thereafter when the dual-sorption model prevails. The initial half-life after vehicle removal with a low donor concentration is longer than that with a higher donor concentration. These features, if observed in experiments, may be used as evidence to confirm that the dual-sorption model gives an explanation to the non-linear kinetic behaviour of a permeant.

MeSH terms

  • Administration, Cutaneous
  • Algorithms*
  • Half-Life
  • Linear Models
  • Models, Biological*
  • Numerical Analysis, Computer-Assisted*
  • Pharmacokinetics
  • Skin Absorption / drug effects*