Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

P Magiatis; E Melliou; A L Skaltsounis; S Mitaku; S Léonce; P Renard; A Pierré; G Atassi

doi:10.1021/np9800295

Synthesis and cytotoxic activity of pyranocoumarins of the seselin and xanthyletin series

J Nat Prod. 1998 Aug;61(8):982-6. doi: 10.1021/np9800295.

Authors

P Magiatis¹, E Melliou, A L Skaltsounis, S Mitaku, S Léonce, P Renard, A Pierré, G Atassi

Affiliation

¹ Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, GR-15771 Athens, Greece, and Institut de Recherche SERVIER, 11 rue des Moulineaux, 92150 Suresnes, France.

PMID: 9722480
DOI: 10.1021/np9800295

Abstract

The synthesis of known (3-6) and new (7-10 and 14-22) coumarins in the seselin and xanthyletin series is described. The cytotoxic activity of compounds 3-22 was carried out in vitro on L-1210 cells. The most active compounds were 9, 16, 18, and 20 in the seselin series and 10, 17, and 19 in the xanthyletin series. Structure-activity relationships are discussed.

MeSH terms

Animals
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Coumarins / isolation & purification*
Coumarins / pharmacology
Humans
Leukemia L1210 / drug therapy
Magnetic Resonance Spectroscopy
Mass Spectrometry
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Phytogenic
Coumarins