Treatment of oral chronic graft-versus-host disease with PUVA therapy: case report and literature review

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Aug;86(2):183-7. doi: 10.1016/s1079-2104(98)90123-8.

Abstract

Chronic graft-versus-host disease commonly appears with oral manifestations subsequent to allogeneic bone marrow transplantation. These manifestations include leukoplakia, mucosal atrophy, erythema, ulcers, and xerostomia. Some lesions are resistant to treatment with immunosuppressive medications. Ultraviolet A irradiation therapy with oral psoralen has been shown to be effective in treating these resistant lesions. This article presents a review of the literature and a case report.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Oral
  • Atrophy
  • Bone Marrow Transplantation / adverse effects
  • Drug Resistance
  • Erythema / drug therapy
  • Erythema / immunology
  • Furocoumarins / administration & dosage
  • Furocoumarins / therapeutic use
  • Graft vs Host Disease / drug therapy*
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Leukoplakia, Oral / drug therapy
  • Leukoplakia, Oral / immunology
  • Male
  • Middle Aged
  • Mouth Diseases / drug therapy*
  • Mouth Diseases / immunology
  • Mouth Mucosa / pathology
  • Oral Ulcer / drug therapy
  • Oral Ulcer / immunology
  • PUVA Therapy*
  • Photosensitizing Agents / administration & dosage
  • Photosensitizing Agents / therapeutic use
  • Transplantation, Homologous
  • Xerostomia / drug therapy
  • Xerostomia / immunology

Substances

  • Furocoumarins
  • Immunosuppressive Agents
  • Photosensitizing Agents