Cell adhesion molecules in cord blood hematopoietic progenitors

Bone Marrow Transplant. 1998 Jul:22 Suppl 1:S61-2.

Abstract

We investigated the expression of different cell adhesion molecules on cord blood (CB) and bone marrow (BM) CD34+/CD38+ and CD34+/CD38- cells. CD11a and CD62L were more expressed in CB than in BM CD34+/CD38- subset, suggesting a possible advantage in homing and engraftment. A short exposure to various cytokines increased CD62L expression only in the more differentiated CB and BM CD34+/CD38+ cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Antigens, CD*
  • Antigens, CD34 / analysis
  • Antigens, Differentiation / analysis
  • Bone Marrow Cells / chemistry
  • Bone Marrow Cells / cytology*
  • Cell Adhesion Molecules / analysis*
  • Fetal Blood / chemistry
  • Fetal Blood / cytology*
  • Flow Cytometry
  • Hematopoietic Stem Cells / chemistry*
  • Humans
  • L-Selectin / analysis
  • Lymphocyte Function-Associated Antigen-1 / analysis
  • Membrane Glycoproteins
  • NAD+ Nucleosidase / analysis

Substances

  • Antigens, CD
  • Antigens, CD34
  • Antigens, Differentiation
  • Cell Adhesion Molecules
  • Lymphocyte Function-Associated Antigen-1
  • Membrane Glycoproteins
  • L-Selectin
  • ADP-ribosyl Cyclase
  • CD38 protein, human
  • NAD+ Nucleosidase
  • ADP-ribosyl Cyclase 1