YAC/STS map of 15Mb of Xp21.3-p11.3, at 100kb resolution, with refined comparisons of genetic distances and DMD structure

Gene. 1998 Jul 30;215(2):259-67. doi: 10.1016/s0378-1119(98)00293-5.

Abstract

The 15<HSP SP = "0.25">Mb region between DXS997 and DXS8054 in Xp21.3-p11.3 has been mapped at seven-fold average coverage in yeast artificial chromosomes (YACs) and 100 kb inter-sequence tagged site (STS) distance. YACs from six different collections show self-consistent maps. The STSs include 18 (CA) repeat and one tetranucleotide repeat marker that detect polymorphism, as well as eight well-studied genes, a second site for MXS1 sequences, and three expressed sequence tags (ESTs). One of the ESTs maps to intron 7 of Duchenne muscular dystrophy, and seems to be a processed intronic sequence with a poly(A) tail.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Artificial, Yeast
  • DNA Primers
  • Dinucleotide Repeats
  • Genetic Markers
  • Genetic Variation
  • Genome, Human
  • Humans
  • Molecular Sequence Data
  • Muscular Dystrophies / genetics*
  • Polymerase Chain Reaction
  • Sequence Tagged Sites
  • Transcription, Genetic
  • X Chromosome*

Substances

  • DNA Primers
  • Genetic Markers