Amplification of ABC transporter gene pgpA and of other heavy metal resistance genes in Leishmania tarentolae and their study by gene transfection and gene disruption

Methods Enzymol. 1998:292:182-93. doi: 10.1016/s0076-6879(98)92015-8.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP-Binding Cassette Transporters / biosynthesis*
  • ATP-Binding Cassette Transporters / genetics*
  • Animals
  • Arsenites / pharmacology
  • DNA, Protozoan / isolation & purification
  • DNA, Protozoan / metabolism
  • Drug Resistance, Multiple / genetics*
  • Gene Amplification
  • Genes, Protozoan
  • Leishmania / drug effects
  • Leishmania / genetics*
  • Leishmania / physiology
  • Membrane Glycoproteins / biosynthesis*
  • Membrane Glycoproteins / genetics*
  • Metals, Heavy / pharmacology*
  • Protozoan Proteins*
  • Transfection / methods

Substances

  • ATP-Binding Cassette Transporters
  • Arsenites
  • DNA, Protozoan
  • Membrane Glycoproteins
  • Metals, Heavy
  • PgpA protein, Leishmania
  • Protozoan Proteins
  • arsenite