9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic produced by Micromonospora sp. SA246

J Antibiot (Tokyo). 1997 Jul;50(7):546-50. doi: 10.7164/antibiotics.50.546.

Abstract

9-Hydroxycrisamicin A, a new cytotoxic isochromanquinone antibiotic, was isolated from a soil microorganism SA246 which was identified as Micromonospora sp. The molecular formula of 9-hydroxycrisamicin A was determined as C32H22O13 based on the HRFAB-MS analysis, and the structure was determined by various NMR experiments. 9-Hydroxycrisamicin A showed weak antimicrobial activity against Gram-positive bacteria and strong cytotoxic activity against some human cancer cell lines such as SK-OV-3 (ovarian), HCT15 (colon), SK-MEL-2 (melanoma), A549 (lung), XF498 (central nervous system) with ED50 of 0.47-0.65 microgram/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Antibiotics, Antineoplastic / pharmacology
  • Fermentation
  • Humans
  • In Vitro Techniques
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Micromonospora / classification
  • Micromonospora / metabolism*
  • Naphthoquinones / isolation & purification
  • Soil Microbiology*
  • Tumor Cells, Cultured / drug effects

Substances

  • 9-hydroxycrisamicin A
  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Naphthoquinones